كتاب  Enrofloxacin pharmacokinetics in the European cuttlefish, Sepia officinalis, after a single i.v. injection and bath administrationكتب الطب

كتاب Enrofloxacin pharmacokinetics in the European cuttlefish, Sepia officinalis, after a single i.v. injection and bath administration

المكتبة الإلكترونيّة لتحميل و قراءة الكتب المصوّرة بنوعية PDF و تعمل على الهواتف الذكية والاجهزة الكفيّة أونلاين 📖 حصريا قراءة كتاب Enrofloxacin pharmacokinetics in the European cuttlefish, Sepia officinalis, after a single i.v. injection and bath administration أونلاين PDF 2018.

وصف الكتاب : Enrofloxacin pharmacokinetics in the European cuttlefish, Sepia officinalis, after a single i.v. injection and bath administration من كتب طب بيطرى Enrofloxacin pharmacokinetics in the European cuttlefish, Sepia officinalis , after a single i.v. injection and bath administration S. R. GORE* C. A. HARMS* B. KUKANICH* J. FORSYTHE  G. A. LEWBART* & M. G. PAPICH* * College of Veterinary Medicine, North Carolina State University, Raleigh, NC;  National Research Center for Cephalopods, University of Texas Medical Branch, Marine Biomedical Institute, Galveston, TX, USA Gore, S. R., Harms, C. A., KuKanich, B., Forsythe, J., Lewbart, G. A., Papich, M. G. Enrofloxacin pharmacokinetics in the European cuttlefish, Sepia officinalis , after a single i.v. injection and bath administration. J. vet. Pharmacol. Therap. 28, 433–439. Enrofloxacin pharmacokinetics were studied in European cuttlefish, Sepia officinalis , after a single 5 mg/kg i.v. injection or a 2.5 mg/L 5 h bath. A pilot study with two animals was also performed following a 10 mg/kg p.o. administration. The concentration of enrofloxacin in hemolymph was assayed using high-performance liquid chromatography (HPLC) and pharmacokinetic parameters were derived from compartmental methods. In the i.v. study, the terminal half-life ( t 1/2 ), apparent volume of distribution, and systemic clearance were respectively 1.81 h, 385 mL/kg, and 4.71 mL/min/kg. Following bath administration the t 1/2 , peak hemolymph concentration ( C max ), and area under the curve to infinity ( AUC 0 ) ¥ ) were 1.01 h, 0.5 ± 0.12 l g/mL, and 0.98 l g Æ h/ mL, respectively. After oral administration, the t 1/2 , C max , and AUC 0 ) ¥ were 1.01 h, 10.95 l g/mL, 26.71 l g Æ h/mL, respectively. The active metabolite of enrofloxacin, ciprofloxacin, was not detected in any samples tested. The hemolymph concentration was still above minimum inhibitory concentration ( MIC ) values for shrimp and fish bacterial isolates at 6 h after i.v. administra- tion, therefore, a dose of 5 mg/kg i.v. every 8–12 h is suggested for additional studies of efficacy. The C max value for the water bath was lower than for the i.v. study, but a bath of 2.5 mg/L for 5 h once to twice daily is suggested for additional studies to test efficacy against highly susceptible organisms. Although only two animals were used for the oral study, a dose of 10 mg/kg produced hemolymph concentrations of enrofloxacin that were in a range consistent with therapeutic efficacy in other species. (Paper received 24 November 2004; accepted for publication 15 July 2005) Dr Mark G. Papich, Department of Molecular Biomedical Sciences, College of Veterinary Medicine, North Carolina State University, 4700 Hillsborough Street, Raleigh, NC 27606, USA. E-mail: [email protected]
عدد مرات التحميل : 5131 مرّة .
تم اضافته في : السبت , 26 مارس 2016م.
نوع الكتاب : PDF .
حجم الكتاب عند التحميل : 103.06 كيلوبايت .
ولتسجيل ملاحظاتك ورأيك حول الكتاب يمكنك المشاركه في التعليقات من هنا:

Enrofloxacin pharmacokinetics in the European cuttlefish, Sepia officinalis, after a single i.v. injection and bath administration من كتب طب بيطرى

Enrofloxacin pharmacokinetics in the European cuttlefish,
Sepia officinalis
,
after a single i.v. injection and bath administration
S. R. GORE*
C. A. HARMS*
B. KUKANICH*
J. FORSYTHE

G. A. LEWBART* &
M. G. PAPICH*
*
College of Veterinary Medicine,
North Carolina State University,
Raleigh, NC;

National Research Center for Cephalopods,
University of Texas Medical Branch,
Marine Biomedical Institute, Galveston, TX,
USA
Gore, S. R., Harms, C. A., KuKanich, B., Forsythe, J., Lewbart, G. A., Papich, M.
G. Enrofloxacin pharmacokinetics in the European cuttlefish,
Sepia officinalis
,
after a single i.v. injection and bath administration.
J. vet. Pharmacol. Therap.
28,
433–439.
Enrofloxacin pharmacokinetics were studied in European cuttlefish,
Sepia
officinalis
, after a single 5 mg/kg i.v. injection or a 2.5 mg/L 5 h bath. A pilot
study with two animals was also performed following a 10 mg/kg p.o.
administration. The concentration of enrofloxacin in hemolymph was assayed
using high-performance liquid chromatography (HPLC) and pharmacokinetic
parameters were derived from compartmental methods. In the i.v. study, the
terminal half-life (
t
1/2
), apparent volume of distribution, and systemic clearance
were respectively 1.81 h, 385 mL/kg, and 4.71 mL/min/kg. Following bath
administration the
t
1/2
, peak hemolymph concentration (
C
max
), and area under
the curve to infinity (
AUC
0
)
¥
) were 1.01 h, 0.5 ± 0.12
l
g/mL, and 0.98
l
g
Æ
h/
mL, respectively. After oral administration, the
t
1/2
,
C
max
, and
AUC
0
)
¥
were
1.01 h, 10.95
l
g/mL, 26.71
l
g
Æ
h/mL, respectively. The active metabolite of
enrofloxacin, ciprofloxacin, was not detected in any samples tested. The
hemolymph concentration was still above minimum inhibitory concentration
(
MIC
) values for shrimp and fish bacterial isolates at 6 h after i.v. administra-
tion, therefore, a dose of 5 mg/kg i.v. every 8–12 h is suggested for additional
studies of efficacy. The
C
max
value for the water bath was lower than for the i.v.
study, but a bath of 2.5 mg/L for 5 h once to twice daily is suggested for
additional studies to test efficacy against highly susceptible organisms.
Although only two animals were used for the oral study, a dose of 10 mg/kg
produced hemolymph concentrations of enrofloxacin that were in a range
consistent with therapeutic efficacy in other species.
(Paper received 24 November 2004; accepted for publication 15 July 2005)
Dr Mark G. Papich, Department of Molecular Biomedical Sciences, College of
Veterinary Medicine, North Carolina State University, 4700 Hillsborough Street,
 



اذا اعجبك الكتاب فضلاً اضغط على أعجبني
و يمكنك تحميله من هنا:

تحميل  Enrofloxacin pharmacokinetics in the European cuttlefish, Sepia officinalis, after a single i.v. injection and bath administration



كتب اخرى في كتب طب بيطرى

Epsiprantel PDF

قراءة و تحميل كتاب Epsiprantel PDF مجانا

Exogenous control of follicular wave emergence in cattle PDF

قراءة و تحميل كتاب Exogenous control of follicular wave emergence in cattle PDF مجانا

Flow cytometric evaluation of selected antimicrobial efficacy for clearance of Anaplasma marginale in short-term erythrocyte cultures PDF

قراءة و تحميل كتاب Flow cytometric evaluation of selected antimicrobial efficacy for clearance of Anaplasma marginale in short-term erythrocyte cultures PDF مجانا

Enrofloxacin to Control Anaplasma marginale Infections PDF

قراءة و تحميل كتاب Enrofloxacin to Control Anaplasma marginale Infections PDF مجانا

Enrofloxacin serum bioactivity in bottlenose dolphins, Tursiops truncatus, following oral administration of 5 mg per kg in whole fish PDF

قراءة و تحميل كتاب Enrofloxacin serum bioactivity in bottlenose dolphins, Tursiops truncatus, following oral administration of 5 mg per kg in whole fish PDF مجانا

Fallibility of faecal consistency as a criterion of success in the evaluation of oral fluid therapy for calf diarrhoea PDF

قراءة و تحميل كتاب Fallibility of faecal consistency as a criterion of success in the evaluation of oral fluid therapy for calf diarrhoea PDF مجانا

Enteral Feeding of 3 Mature Cows by Rumenostomy (p 779-781) PDF

قراءة و تحميل كتاب Enteral Feeding of 3 Mature Cows by Rumenostomy (p 779-781) PDF مجانا

Enterotoxemia in a Cow due to Clostridium perfringens Type A PDF

قراءة و تحميل كتاب Enterotoxemia in a Cow due to Clostridium perfringens Type A PDF مجانا

المزيد من كتب الطب في مكتبة كتب الطب , المزيد من كتب صيدلة في مكتبة كتب صيدلة , المزيد من الطب البشرى العام في مكتبة الطب البشرى العام , المزيد من كتب تمريض في مكتبة كتب تمريض , المزيد من كتب طب بيطرى في مكتبة كتب طب بيطرى , المزيد من كتب طب اسنان في مكتبة كتب طب اسنان , المزيد من الطب التكميلي - الطب البديل في مكتبة الطب التكميلي - الطب البديل , المزيد من كتب علاج طبيعى في مكتبة كتب علاج طبيعى
عرض كل كتب الطب ..
اقرأ المزيد في مكتبة كتب تقنية , اقرأ المزيد في مكتبة كتب إسلامية , اقرأ المزيد في مكتبة كتب الهندسة و التكنولوجيا , اقرأ المزيد في مكتبة كتب التنمية البشرية , اقرأ المزيد في مكتبة الكتب التعليمية , اقرأ المزيد في مكتبة كتب التاريخ , اقرأ المزيد في مكتبة الطفل قصص و مجلات , اقرأ المزيد في مكتبة كتب تعلم اللغات , اقرأ المزيد في مكتبة القصص و الروايات و المجلات , اقرأ المزيد في مكتبة كتب الطب , اقرأ المزيد في مكتبة الكتب و الموسوعات العامة , اقرأ المزيد في مكتبة كتب الأدب , اقرأ المزيد في مكتبة كتب اللياقة البدنية والصحة العامة , اقرأ المزيد في مكتبة كتب الروايات الأجنبية والعالمية , اقرأ المزيد في مكتبة كتب علوم سياسية و قانونية , اقرأ المزيد في مكتبة الكتب الغير مصنّفة , اقرأ المزيد في مكتبة كتب الطبخ و الديكور , اقرأ المزيد في مكتبة كتب المعاجم و اللغات , اقرأ المزيد في مكتبة كتب علوم عسكرية و قانون دولي
جميع مكتبات الكتب ..