كتاب Prognostic Value of Bioactive Adrenomedullin in Critically Ill Patients

This study's objective is to assess the prognostic value of the serum level of admission bio-ADM in critically ill patients. In this observational prospective study, patients who were admitted to Minia University Hospitals' medical critical care unit between December 2020 and November 2021 underwent a complete blood count, CRP , renal and liver function tests and blood culture. All patients had their bio-adrenomedullin levels evaluated by ELISA at the time of admission. The work included 114 patients who were subdivided into 3 groups: non-septic group including SIRS patients with negative blood culture (n=44), mild sepsis group including patients with SOFA score ≥2 without organ dysfunction (n=26), and severe sepsis group including sepsis patients with organ dysfunction (n=44). There was a significant difference in distribution of the quartiles of bio-ADM between survivor and non-survivors. Most of the non-survivors in our cohort were in the 4th quartile of bio-ADM (38.9%) while 45% of the survivors were in the 1st quartile of bio-ADM. The levels of Bio-ADM were positively correlated with CRP (r-value: 0.65, p-value < 0.001) and SOFA score (r-value: 0.63, p-value < 0.001). Using receiver operating characteristic (ROC) curve to determine the prognostic accuracy of bio-ADM, CRP, and SOFA score revealed higher area under curve (AUC) for bio-ADM (0.78, 95% CI: 0.69-0.86) followed by CRP (0.66, 95% CI: 0.56-0.76) and SOFA score (0.63, 95% CI: 0.52-0.73). The best cut-off for bio-ADM to predict ICU mortality in our cohort was 121.5 pg/ml with a sensitivity of 85% and a specificity of 61%.
مجموعة من المؤلفين - "مجموعة من المؤلفين"، هو ركن للكتب التي شارك في تأليفها أكتر من كاتب ومؤلف، وهو قسم مميز مليء بالكتب التي تعددت الجهود في إخراجها على أكمل الوجوه.
من كتب الطب البشري - مكتبة كتب الطب.